Can you think of any specific disadvantages to T-cells’ positive and negative selection processes in the thymus? Can you think of ways in which the identified disadvantages will affect T-cell function?

Module 4 Discussion

T-lymphocytes undergo thymic selection whereby they are able to recognize foreign peptides contained in MHCs. Based on this statement, answer the following questions:

• Can you think of any specific disadvantages to T-cells’ positive and negative selection processes in the thymus?
• Can you think of ways in which the identified disadvantages will affect T-cell function?